Description
For radiopharmaceutical quality control
Tec-Control Chromatography tests the radiochemical purity of specific Tc-99m-labeled radiopharmaceuticals. The accompanying chart shows which strips and solvents are required to perform each individual test. Some solvents must be purchased separately (see Sigma-Aldrich chart) due to hazardous material shipping restrictions.
Detailed instruction manuals are packaged with each strip container, although our Radiopharmaceutical QC Procedure Manual (151-000) explains paper chromatography in greater detail.
References:
Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals; A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230.
Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis, A. Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center, Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1.
| RADIOPHARMACEUTICAL | SOLVENT(S) REQUIRED* | STRIPS REQUIRED |
| Aluminum Breakthru | 150-781 10 µg/ml | 150-782 |
| Aluminum Breakthru | 150-783 5 µg/ml | 150-782 |
| Bicisate (Neurolite™) | Ethyl Acetate 99.% | 150-130 |
| Diphosphonate | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Disofenin (Hepatolite™) | 150-160, Distilled H2O | 150-122 & 150-125 |
| DMSA | Acetone (HPLC Grade), | 150-025 |
| DTPA | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Exametazine (Ceretec™) | Ethyl Acetate 99.% |
150-130 |
|
Fluorodeoxyglucose (FDG)
|
Acetone (HPLC Grade) | 150-127 |
| Glucoheptonate | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| HDP | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| MAA | Acetone (HPLC Grade), | 150-001 |
| MAG3 (Mertiatide™) | Acetone, (HPLC Grade), Chloroform 99.8% Tetrahydrofuran 99+% |
150-951 & 150-952 |
| MDP | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Mebrofenin (Cholotec™) | 150-160, Distilled H2O | 150-122 & 150-125 |
| Pyrophosphate | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Sestamibi (Cardiolite™ and Miraluma™) |
Ethyl Acetate 99.% | 150-991 |
| Sulphur Colloid | Acetone (HPLC Grade) | 150-001 |
| Tc-99m (reduced) | Acetone (HPLC Grade), | 150-001 |
| Tc-99m Monoclonal Antibodies | 0.9% Saline | 150-771 |
| Tetrofosmin (Myoview™) | Ethyl Acetate 99.% |
150-971 |
| In-111 Octreotide (Octreoscan™) |
150-773 & 0.9% Saline | 150-771 ** |
| In-111 Monoclonal Antibodies |
150-773 & 0.9% Saline | 150-771 ** |
| In-111/Y-90 Zevalin™ | 0.9% Saline | 150-772 |
| I-131 Monoclonal Antibodies And Neutrospec™ |
0.9% Saline | 150-771 |
* See Sigma-Aldrich product matrix for solvents.
** Note: A Well Plate is suggested to perform QC on these radiopharmaceuticals