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Tec-Control Aluminium Breakthru Kit

Biodex

Tec-Control Aluminium Breakthru Kit


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For radiopharmaceutical quality control

The Aluminium Break­thru Kit provides a ra­pid, easy and inexpensive way to test aqueous solutions, particularly per­tech­netate generator eluate, for trace quantities of aluminium. Aluminium forms an intense red precipitate with the indicator paper, and the intensity of the colour is directly proportional to the amount of aluminium in the solution. The USP allows a concentration of aluminium ion in an injection 10 micrograms per millilitre (10 µg/ml) in technetium 99m eluate prepared from Molybdenum 99 formed as a result of uranium fission.

Simple Procedure:

  1. Place a drop of the eluate or solution to be tested on the indicator paper. The best procedure is to form a hanging drop using a 19-22G needle.
  2. Place a drop of the standard aluminium solution on the indicator paper. Use the same size drop.
  3. Compare the intensity of the red spot formed. If the eluate spot is less intense than the standard solution, the eluate contains less than 10µg/ml aluminium.

References:

    Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals; A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230.

    Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis, A. Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center, Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1. 


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