iNSiGHT DXA Preclinical Cabinet X-Ray


iNSiGHT DXA Preclinical Cabinet X-Ray


System Overview

The iNSiGHT DXA system is a state-of-the-art in vivo Dual Energy X-Ray Absorptiometry (DXA/DEXA) technology designed for preclinical research. It provides a comprehensive solution for evaluating a wide range of metabolic disorders, such as osteoporosis, arthritis, diabetes, obesity, and musculoskeletal pathologies, including bone regeneration and muscle wasting diseases.

This system is equipped with a fully shielded X-ray cabinet, making it suitable for small animal DXA applications, with a focus on mice, rats, and animals of similar size (up to 5kg). It provides fast and efficient body composition measurements. The system’s fast scan times of 25 seconds, combined with its low-dose radiation, make it ideal for longitudinal studies.

The iNSiGHT system uses dual energy x-rays to obtain highly accurate and reproducible body composition measurements. The system assigns each pixel to one of three compartments: fat mass, non-bone/lean mass, or bone mineral content, providing measurements such as bone mineral density, bone mineral content, bone area, tissue area, fat tissue as a percentage and weight, lean tissue as a percentage and weight, and total weight in grams.

This technology is non-invasive, non-destructive, and does not require any pre-treatment of the animal, contrast, or substrate injection. The iNSiGHT system also provides specific bone length measurements that can be drawn from the 2D x-ray image.

Features & Benefits

Easy data acquisition
No preparation steps other than anesthesia are required. This can be done using the integrated anesthesia system, or with injectable anesthesia if desired.

Once ready the imaging subject is placed on stage and imaging can begin, using the easy-to-use acquisition software.

25 second scan time
The iNSiGHT has the fastest scan time on the market, allowing for high-throughput imaging.
Large scan area

The iNSiGHT system allows for a variety of animal models and tissue samples to be imaged, from 10g ~ 5kg. (Scan Area: 16.5 x 25.5 cm)

This allows users to image not only mice and rats, but other species such as non-human primates, fish, rabbits, etc.

Low-dose radiation
The iNSiGHT was designed to minimize the ionizing radiation (0.66 mGy) required to generate images and data. This minimization prevents any effect of the image acquisition on the subject, allowing for multiple imaging time points over the course of a longitudinal study.
Adjustable field of view and resolution
The iNSiGHT system has several levels of magnification, adjust the field of view (FOV) and resolution to suite your specific needs.

(100µm – up to 31µm in Digital Radiography Mode)

Comprehensive set of images and parameters
In a single scan (25 seconds) the x-ray attenuated image, bone mineral density map and color map are generated. 

A number of parameters are calculated from these images – either from the whole animal or for user defined regions of interest (ROI):

  • Bone Mineral Content (BMC) (g/cm2)
  • Bone Mineral Density (BMD) g)
  • Bone area (cm2)
  • Tissue area (cm2)
  • Fat tissue (mass and percentage) (g & %)
  • Lean tissue (mass and percentage) (g & %)
  • Total mass (g)

Technical Specifications

  •  Scan Method : Cone Beam
  •  Animal Size : Mice, rats, and animals of similar size (up to 5kg)
  •  Image Area (maximum) : 16.5 x 25.5cm
  •  Pixel Size : 100µm at 1.2X 31µm at 4X with DR Mode
  •  Operating System : Windows 10, 64bit
  •  Dimensions (WxDxH) : 66 x 61 x 113 cm
  •  Power : 110/240VAC, 50/60Hz, 200VA
  •  Operating Temp : 10 ~ 40oC

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